Targeting transcription factors in cancer
AS Bhagwat, CR Vakoc - Trends in cancer, 2015 - cell.com
Trends in cancer, 2015•cell.com
Transcription factors (TFs) are commonly deregulated in the pathogenesis of human cancer
and are a major class of cancer cell dependencies. Consequently, targeting of TFs can be
highly effective in treating particular malignancies, as highlighted by the clinical efficacy of
agents that target nuclear hormone receptors. In this review we discuss recent advances in
our understanding of TFs as drug targets in oncology, with an emphasis on the emerging
chemical approaches to modulate TF function. The remarkable diversity and potency of TFs …
and are a major class of cancer cell dependencies. Consequently, targeting of TFs can be
highly effective in treating particular malignancies, as highlighted by the clinical efficacy of
agents that target nuclear hormone receptors. In this review we discuss recent advances in
our understanding of TFs as drug targets in oncology, with an emphasis on the emerging
chemical approaches to modulate TF function. The remarkable diversity and potency of TFs …
Transcription factors (TFs) are commonly deregulated in the pathogenesis of human cancer and are a major class of cancer cell dependencies. Consequently, targeting of TFs can be highly effective in treating particular malignancies, as highlighted by the clinical efficacy of agents that target nuclear hormone receptors. In this review we discuss recent advances in our understanding of TFs as drug targets in oncology, with an emphasis on the emerging chemical approaches to modulate TF function. The remarkable diversity and potency of TFs as drivers of cell transformation justifies a continued pursuit of TFs as therapeutic targets for drug discovery.
cell.com