[HTML][HTML] The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
AJ Brown, SM Goldsworthy, AA Barnes… - Journal of Biological …, 2003 - ASBMB
GPR41 and GPR43 are related members of a homologous family of orphan G protein-
coupled receptors that are tandemly encoded at a single chromosomal locus in both
humans and mice. We identified the acetate anion as an agonist of human GPR43 during
routine ligand bank screening in yeast. This activity was confirmed after transient
transfection of GPR43 into mammalian cells using Ca 2+ mobilization and [35 S] guanosine
5′-O-(3-thiotriphosphate) binding assays and by coexpression with GIRK G protein …
coupled receptors that are tandemly encoded at a single chromosomal locus in both
humans and mice. We identified the acetate anion as an agonist of human GPR43 during
routine ligand bank screening in yeast. This activity was confirmed after transient
transfection of GPR43 into mammalian cells using Ca 2+ mobilization and [35 S] guanosine
5′-O-(3-thiotriphosphate) binding assays and by coexpression with GIRK G protein …