Targeted and nontargeted bone remodeling: relationship to basic multicellular unit origination and progression

AM Parfitt - Bone, 2002 - Elsevier
AM Parfitt
Bone, 2002Elsevier
Most discussions of bone remodeling focus on how it is influenced by hormones, cytokines,
growth factors, and other molecules, and pay no attention to why it occurs. All physiologic
processes are aimed at something, however, and it is impossible to understand how they
are regulated without some criteria of success or failure. In this mini-review, I examine the
purposes and instruments of bone remodeling and how they are related.
Most discussions of bone remodeling focus on how it is influenced by hormones, cytokines, growth factors, and other molecules, and pay no attention to why it occurs. All physiologic processes are aimed at something, however, and it is impossible to understand how they are regulated without some criteria of success or failure. In this mini-review, I examine the purposes and instruments of bone remodeling and how they are related.
Elsevier