[HTML][HTML] Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by β-catenin-dependent and-independent signaling …
Genetic studies in humans and mice have revealed an important role of the Wnt signaling
pathway in the regulation of bone mass, resulting from potent effects on the control of
osteoblast progenitor proliferation, commitment, differentiation, and perhaps osteoblast
apoptosis. To establish the linkage between Wnts and osteoblast survival and to elucidate
the molecular pathways that link the two, we have utilized three cell models: the
uncommitted bipotential C2C12 cells, the pre-osteoblastic cell line MC3T3-E1, and bone …
pathway in the regulation of bone mass, resulting from potent effects on the control of
osteoblast progenitor proliferation, commitment, differentiation, and perhaps osteoblast
apoptosis. To establish the linkage between Wnts and osteoblast survival and to elucidate
the molecular pathways that link the two, we have utilized three cell models: the
uncommitted bipotential C2C12 cells, the pre-osteoblastic cell line MC3T3-E1, and bone …