Sodium butyrate stimulates mineralized nodule formation and osteoprotegerin expression by human osteoblasts
T Katono, T Kawato, N Tanabe, N Suzuki, T Iida… - Archives of oral …, 2008 - Elsevier
OBJECTIVE: Butyric acid (sodium butyrate; BA) is a major metabolic by-product of main
periodontopathic bacteria present in subgingival plaque. In the present study, we examined
the effects of BA on cell proliferation, alkaline phosphatase (ALPase) activity, mineralized
nodule formation, extracellular matrix protein expression, macrophage colony-stimulating
factor (M-CSF), and osteoprotegerin (OPG) in normal human osteoblasts. METHODS: The
cells were cultured with 0, 10− 8, 10− 6 or 10− 4M BA for up to 12 days. Mineralized nodule …
periodontopathic bacteria present in subgingival plaque. In the present study, we examined
the effects of BA on cell proliferation, alkaline phosphatase (ALPase) activity, mineralized
nodule formation, extracellular matrix protein expression, macrophage colony-stimulating
factor (M-CSF), and osteoprotegerin (OPG) in normal human osteoblasts. METHODS: The
cells were cultured with 0, 10− 8, 10− 6 or 10− 4M BA for up to 12 days. Mineralized nodule …