Wnt signaling in bone and muscle
MA Rudnicki, BO Williams - Bone, 2015 - Elsevier
Bone, 2015•Elsevier
Wnt signaling plays key roles in many aspects of development. In this review, we will briefly
describe the components of signaling pathways induced by Wnt ligands and then describe
the current state of research as this applies to aspects of development and disease as it
relates to skeletal muscle and bone. We will conclude with a discussion of the parallels and
differences in Wnt signaling in these two contexts and how these pathways are being (or
could potentially be) targeted for therapeutic treatment of musculoskeletal diseases. This …
describe the components of signaling pathways induced by Wnt ligands and then describe
the current state of research as this applies to aspects of development and disease as it
relates to skeletal muscle and bone. We will conclude with a discussion of the parallels and
differences in Wnt signaling in these two contexts and how these pathways are being (or
could potentially be) targeted for therapeutic treatment of musculoskeletal diseases. This …
Abstract
Wnt signaling plays key roles in many aspects of development. In this review, we will briefly describe the components of signaling pathways induced by Wnt ligands and then describe the current state of research as this applies to aspects of development and disease as it relates to skeletal muscle and bone. We will conclude with a discussion of the parallels and differences in Wnt signaling in these two contexts and how these pathways are being (or could potentially be) targeted for therapeutic treatment of musculoskeletal diseases.
This article is part of a Special Issue entitled “Muscle Bone Interactions”.
Elsevier