[HTML][HTML] The monocarboxylate transporter 4 is required for glycolytic reprogramming and inflammatory response in macrophages
There has been fast growing evidence showing that glycolysis plays a critical role in the
activation of immune cells. Enhanced glycolysis leads to increased formation of intracellular
lactate that is exported to the extracellular environment by monocarboxylate transporter 4
(MCT4). Although the biological activities of extracellular lactate have been well studied, it is
less understood how the lactate export is regulated or whether lactate export affects
glycolysis during inflammatory activation. In this study, we found that MCT4 is up-regulated …
activation of immune cells. Enhanced glycolysis leads to increased formation of intracellular
lactate that is exported to the extracellular environment by monocarboxylate transporter 4
(MCT4). Although the biological activities of extracellular lactate have been well studied, it is
less understood how the lactate export is regulated or whether lactate export affects
glycolysis during inflammatory activation. In this study, we found that MCT4 is up-regulated …