Molecular mechanisms of IFN-γ to up-regulate MHC class I antigen processing and presentation
F Zhou - International reviews of immunology, 2009 - Taylor & Francis
International reviews of immunology, 2009•Taylor & Francis
IFN-γ up-regulates MHC class I expression and antigen processing and presentation on
cells, since IFN-γ can induce multiple gene expressions that are related to MHC class I
antigen processing and presentation. MHC class I antigen presentation-associated gene
expression is initiated by IRF-1. IRF-1 expression is initiated by phosphorylated STAT1. IFN-
γ binds to IFN receptors, and then activates JAK1/JAK2/STAT1 signal transduction via
phosphorylation of JAK and STAT1 in cells. IFN-γ up-regulates MHC class I antigen …
cells, since IFN-γ can induce multiple gene expressions that are related to MHC class I
antigen processing and presentation. MHC class I antigen presentation-associated gene
expression is initiated by IRF-1. IRF-1 expression is initiated by phosphorylated STAT1. IFN-
γ binds to IFN receptors, and then activates JAK1/JAK2/STAT1 signal transduction via
phosphorylation of JAK and STAT1 in cells. IFN-γ up-regulates MHC class I antigen …
IFN-γ up-regulates MHC class I expression and antigen processing and presentation on cells, since IFN-γ can induce multiple gene expressions that are related to MHC class I antigen processing and presentation. MHC class I antigen presentation-associated gene expression is initiated by IRF-1. IRF-1 expression is initiated by phosphorylated STAT1. IFN-γ binds to IFN receptors, and then activates JAK1/JAK2/STAT1 signal transduction via phosphorylation of JAK and STAT1 in cells. IFN-γ up-regulates MHC class I antigen presentation via activation of JAK/STAT1 signal transduction pathway. Mechanisms of IFN-γ to enhance MHC class I antigen processing and presentation were summarized in this literature review.
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