[HTML][HTML] TGF-β1 alters esophageal epithelial barrier function by attenuation of claudin-7 in eosinophilic esophagitis
N Nguyen, SD Fernando, KA Biette, JA Hammer… - Mucosal …, 2018 - Elsevier
Barrier dysfunction has been implicated in the pathophysiology of eosinophilic esophagitis
(EoE). Transforming growth factor-β1 (TGF-β1), a potent pleiotropic molecule, is increased in
EoE; however, no study has evaluated its influence on esophageal epithelial barrier. We
hypothesized that TGF-β1 regulates barrier dysfunction in EoE. We aimed to determine the
role of TGF-β1 in the epithelial barrier in models of EoE. To examine the impact of TGF-β1
on esophageal barrier, immortalized human esophageal epithelial (EPC2-hTERT) cells …
(EoE). Transforming growth factor-β1 (TGF-β1), a potent pleiotropic molecule, is increased in
EoE; however, no study has evaluated its influence on esophageal epithelial barrier. We
hypothesized that TGF-β1 regulates barrier dysfunction in EoE. We aimed to determine the
role of TGF-β1 in the epithelial barrier in models of EoE. To examine the impact of TGF-β1
on esophageal barrier, immortalized human esophageal epithelial (EPC2-hTERT) cells …