Adipocyte biology in breast cancer: From silent bystander to active facilitator

J Choi, YJ Cha, JS Koo - Progress in lipid research, 2018 - Elsevier
Adipocytes account for the largest proportion among the cells that comprise breast tissue;
therefore, they are considered to be a critical cell type in the tumor microenvironment of
breast cancer. In breast cancer, adipocytes are not only found adjacent to cancer cells, but
they also play an active role in the entire process of cancer development, progression,
metastasis, and treatment response. Factors including the secretion of adipokines such as
leptin and adiponectin, as well as autotaxin, interleukin 6, tumor necrosis factor alpha, and …