Adipose tissue attracts and protects acute lymphoblastic leukemia cells from chemotherapy
R Pramanik, X Sheng, B Ichihara, N Heisterkamp… - Leukemia research, 2013 - Elsevier
Obesity is associated with an increased risk of acute lymphoblastic leukemia (ALL) relapse.
Using mouse and cell co-culture models, we investigated whether adipose tissue attracts
ALL to a protective microenvironment. Syngeneically implanted ALL cells migrated into
adipose tissue within ten days. In vitro, murine ALL cells migrated towards adipose tissue
explants and 3T3-L1 adipocytes. Human and mouse ALL cells migrated toward adipocyte
conditioned media, which was mediated by SDF-1α. In addition, adipose tissue explants …
Using mouse and cell co-culture models, we investigated whether adipose tissue attracts
ALL to a protective microenvironment. Syngeneically implanted ALL cells migrated into
adipose tissue within ten days. In vitro, murine ALL cells migrated towards adipose tissue
explants and 3T3-L1 adipocytes. Human and mouse ALL cells migrated toward adipocyte
conditioned media, which was mediated by SDF-1α. In addition, adipose tissue explants …