[HTML][HTML] Isozyme-dependent sensitivity of adenylyl cyclases to P-site-mediated inhibition by adenine nucleosides and nucleoside 3′-polyphosphates
RA Johnson, L Désaubry, G Bianchi, I Shoshani… - Journal of Biological …, 1997 - ASBMB
Recombinant adenylyl cyclase isozyme Types I, II, VI, VII, and three splice variants of Type
VIII were compared for their sensitivity to P-site-mediated inhibition by several adenine
nucleoside derivatives and by the family of recently synthesized adenine nucleoside 3′-
polyphosphates (Désaubry, L., Shoshani, I., and Johnson, RA (1996) J. Biol. Chem. 271,
14028-14034). Inhibitory potencies were dependent on isozyme type, the mode of activation
of the respective isozymes, and on P-site ligand. For the nucleoside derivatives potency …
VIII were compared for their sensitivity to P-site-mediated inhibition by several adenine
nucleoside derivatives and by the family of recently synthesized adenine nucleoside 3′-
polyphosphates (Désaubry, L., Shoshani, I., and Johnson, RA (1996) J. Biol. Chem. 271,
14028-14034). Inhibitory potencies were dependent on isozyme type, the mode of activation
of the respective isozymes, and on P-site ligand. For the nucleoside derivatives potency …