[HTML][HTML] Endothelial-Mesenchymal Transition in Vascular Calcification of Ins2Akita/+ Mice
PJ Guihard, J Yao, AM Blazquez-Medela… - PloS one, 2016 - journals.plos.org
PloS one, 2016•journals.plos.org
Endothelial-mesenchymal transition (EndMT) drives endothelium to contribute to normal
development and disease processes. Here, we report that EndMTs occur in the diabetic
endothelium of Ins2 Akita/wt mouse, and show that induction of sex determining region Y-
box 2 (Sox2) is a mediator of excess BMP signaling that results in activation of EndMTs and
increased vascular calcification. We also find an induction of a complex of serine proteases
in the diabetic endothelium, required for the up-regulation of Sox2. Our results suggest that …
development and disease processes. Here, we report that EndMTs occur in the diabetic
endothelium of Ins2 Akita/wt mouse, and show that induction of sex determining region Y-
box 2 (Sox2) is a mediator of excess BMP signaling that results in activation of EndMTs and
increased vascular calcification. We also find an induction of a complex of serine proteases
in the diabetic endothelium, required for the up-regulation of Sox2. Our results suggest that …
Endothelial-mesenchymal transition (EndMT) drives endothelium to contribute to normal development and disease processes. Here, we report that EndMTs occur in the diabetic endothelium of Ins2Akita/wt mouse, and show that induction of sex determining region Y-box 2 (Sox2) is a mediator of excess BMP signaling that results in activation of EndMTs and increased vascular calcification. We also find an induction of a complex of serine proteases in the diabetic endothelium, required for the up-regulation of Sox2. Our results suggest that EndMTs contribute to vascular calcification in diabetic arteries.
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