Reduced thymocyte development in sonic hedgehog knockout embryos
DK Shah, AL Hager-Theodorides… - The Journal of …, 2004 - journals.aai.org
DK Shah, AL Hager-Theodorides, SV Outram, SE Ross, A Varas, T Crompton
The Journal of Immunology, 2004•journals.aai.orgThe Hedgehog family of secreted intercellular signaling molecules are regulators of
patterning and organogenesis during animal development. In this study we provide genetic
evidence that Sonic Hedgehog (Shh) has a role in the control of murine T cell development.
Analysis of Shh−/− mouse embryos revealed that Shh regulates fetal thymus cellularity and
thymocyte differentiation. Shh is necessary for expansion of CD4− CD8− double-negative
(DN) thymocytes and for efficient transition from the earliest CD44+ CD25− DN population to …
patterning and organogenesis during animal development. In this study we provide genetic
evidence that Sonic Hedgehog (Shh) has a role in the control of murine T cell development.
Analysis of Shh−/− mouse embryos revealed that Shh regulates fetal thymus cellularity and
thymocyte differentiation. Shh is necessary for expansion of CD4− CD8− double-negative
(DN) thymocytes and for efficient transition from the earliest CD44+ CD25− DN population to …
Abstract
The Hedgehog family of secreted intercellular signaling molecules are regulators of patterning and organogenesis during animal development. In this study we provide genetic evidence that Sonic Hedgehog (Shh) has a role in the control of murine T cell development. Analysis of Shh−/− mouse embryos revealed that Shh regulates fetal thymus cellularity and thymocyte differentiation. Shh is necessary for expansion of CD4− CD8− double-negative (DN) thymocytes and for efficient transition from the earliest CD44+ CD25− DN population to the subsequent CD44+ CD25+ DN population and from DN to CD4+ CD8+ double-positive cells.
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