Recombinant human granulocyte colony-stimulating factor promotes wound healing in a patient with congenital neutropenia
GE Besner, PL Glick, MP Karp, WC Wang… - Journal of pediatric …, 1992 - Elsevier
We report a patient with congenital neutropenia or Kostmann's Syndrome who suffered
many complications after presenting with Clostridium septicum enterocolitis, including
absence of wound healing. Because of several reports of the use of granulocyte colony-
stimulating factor (G-CSF) in patients with various complications of neutropenia, we treated
this patient with recombinant human (rh) G-CSF. We found that once rhG-CSF restored
neutrophil counts to normal, progressive wound healing followed. Thus, rhG-CSF therapy …
many complications after presenting with Clostridium septicum enterocolitis, including
absence of wound healing. Because of several reports of the use of granulocyte colony-
stimulating factor (G-CSF) in patients with various complications of neutropenia, we treated
this patient with recombinant human (rh) G-CSF. We found that once rhG-CSF restored
neutrophil counts to normal, progressive wound healing followed. Thus, rhG-CSF therapy …