Toll like receptor-2 regulates production of glial-derived neurotrophic factors in murine intestinal smooth muscle cells

P Brun, S Gobbo, V Caputi, L Spagnol… - Molecular and Cellular …, 2015 - Elsevier
Gut microbiota-innate immunity axis is emerging as a key player to guarantee the structural
and functional integrity of the enteric nervous system (ENS). Alterations in the composition of
the gut microbiota, derangement in signaling of innate immune receptors such as Toll-like
receptors (TLRs), and modifications in the neurochemical coding of the ENS have been
associated with a variety of gastrointestinal disorders. Indeed, TLR2 activation by microbial
products controls the ENS structure and regulates intestinal neuromuscular function …