As low molecular weight proteins, restriction from glomerular filtration is minimized,
permitting significant amounts of Ig light chains to be endocytosed into the proximal tubule
epithelium, particularly in plasma cell dyscrasias. Recent studies have shown that this effect
of concentrating light chains within the proximal tubule alters cell function. This study
demonstrated that light chains belonged to a class of proteins that are capable of catalyzing
the formation of hydrogen peroxide. Sufficient amounts of hydrogen peroxide were produced …