[HTML][HTML] Reactive oxygen species are downstream products of TRAF-mediated signal transduction
NS Chandel, PT Schumacker, RH Arch - Journal of Biological Chemistry, 2001 - ASBMB
Members of the TNFR (tumor necrosis factor receptor) superfamily are involved in regulating
activation and differentiation of cells as well as cell survival and programmed cell
death/apoptosis. Multimerization of TNFRs can lead to recruitment of TRAFs (TNFR-
associated factors) by the receptors resulting in activation of kinases and transcription
factors, such as c-Jun N-terminal kinase and nuclear factor κB (NF-κB). Signal transduction
triggered by TNF-α also induces an increase in intracellular reactive oxygen species (ROS) …
activation and differentiation of cells as well as cell survival and programmed cell
death/apoptosis. Multimerization of TNFRs can lead to recruitment of TRAFs (TNFR-
associated factors) by the receptors resulting in activation of kinases and transcription
factors, such as c-Jun N-terminal kinase and nuclear factor κB (NF-κB). Signal transduction
triggered by TNF-α also induces an increase in intracellular reactive oxygen species (ROS) …