[HTML][HTML] Regulatory T cells interfere with glutathione metabolism in dendritic cells and T cells
Z Yan, SK Garg, R Banerjee - Journal of Biological Chemistry, 2010 - ASBMB
Naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells (Tregs) suppress proliferation of
CD4+ CD25− effector T cells (Teffs) by mechanisms that are not well understood. We have
previously demonstrated a novel mechanism of Treg suppression, ie interference with
extracellular redox remodeling that occurs during activation of T cells by dendritic cells. In
this study, we demonstrate that Treg-mediated redox perturbation is antigen-dependent but
not antigen-specific, is CTLA-4-dependent, and requires cell-cell contact. Furthermore, we …
CD4+ CD25− effector T cells (Teffs) by mechanisms that are not well understood. We have
previously demonstrated a novel mechanism of Treg suppression, ie interference with
extracellular redox remodeling that occurs during activation of T cells by dendritic cells. In
this study, we demonstrate that Treg-mediated redox perturbation is antigen-dependent but
not antigen-specific, is CTLA-4-dependent, and requires cell-cell contact. Furthermore, we …