The NFAT (nuclear factor of activated T-cells) family of transcription factors functions as
integrators of multiple signaling pathways by binding to chromatin in combination with other
transcription factors and coactivators to regulate genes central for many developmental
systems. Recent experimental evidence has shown that the calcineurin/NFAT signaling
pathway is important in axonal growth and guidance during vertebrate development. In fact,
studies with triple NFATc2/c3/c4 mutant mice demonstrate that the extension and …