CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease

H Hadeiba, T Sato, A Habtezion, C Oderup, J Pan… - Nature …, 2008 - nature.com
H Hadeiba, T Sato, A Habtezion, C Oderup, J Pan, EC Butcher
Nature immunology, 2008nature.com
Dendritic cells (DCs) are'professional'antigen-presenting cells that are key in the regulation
of immune responses. Here we characterize a unique subset of tolerogenic DCs that
expressed the chemokine receptor CCR9 and migrated to the CCR9 ligand CCL25, a
chemokine linked to the homing of T cells and DCs to the gut. CCR9+ DCs were of the
plasmacytoid DC (pDC) lineage, had an immature phenotype and rapidly downregulated
CCR9 in response to maturation-inducing pDC-restricted Toll-like receptor ligands. CCR9+ …
Abstract
Dendritic cells (DCs) are 'professional' antigen-presenting cells that are key in the regulation of immune responses. Here we characterize a unique subset of tolerogenic DCs that expressed the chemokine receptor CCR9 and migrated to the CCR9 ligand CCL25, a chemokine linked to the homing of T cells and DCs to the gut. CCR9+ DCs were of the plasmacytoid DC (pDC) lineage, had an immature phenotype and rapidly downregulated CCR9 in response to maturation-inducing pDC-restricted Toll-like receptor ligands. CCR9+ pDCs were potent inducers of regulatory T cell function and suppressed antigen-specific immune responses both in vitro and in vivo, including inhibiting acute graft-versus-host disease induced by allogeneic CD4+ donor T cells in irradiated recipients. Our results identify a highly immunosuppressive population of pDCs present in lymphoid tissues.
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