Biological and pathological activities of interleukin-22
M Perusina Lanfranca, Y Lin, J Fang, W Zou… - Journal of molecular …, 2016 - Springer
Abstract Interleukin (IL)-22, a member of the IL-10 family, is a cytokine secreted by several
types of immune cells including IL-22+ CD4+ T cells (Th22) and IL-22 expressing innate
leukocytes (ILC22). Recent studies have demonstrated that IL-22 is a key component in
mucosal barrier defense, tissue repair, epithelial cell survival, and proliferation. Furthermore,
accumulating evidence has defined both protective and pathogenic properties of IL-22 in a
number of conditions including autoimmune disease, infection, and malignancy. In this …
types of immune cells including IL-22+ CD4+ T cells (Th22) and IL-22 expressing innate
leukocytes (ILC22). Recent studies have demonstrated that IL-22 is a key component in
mucosal barrier defense, tissue repair, epithelial cell survival, and proliferation. Furthermore,
accumulating evidence has defined both protective and pathogenic properties of IL-22 in a
number of conditions including autoimmune disease, infection, and malignancy. In this …
Abstract
Interleukin (IL)-22, a member of the IL-10 family, is a cytokine secreted by several types of immune cells including IL-22+CD4+ T cells (Th22) and IL-22 expressing innate leukocytes (ILC22). Recent studies have demonstrated that IL-22 is a key component in mucosal barrier defense, tissue repair, epithelial cell survival, and proliferation. Furthermore, accumulating evidence has defined both protective and pathogenic properties of IL-22 in a number of conditions including autoimmune disease, infection, and malignancy. In this review, we summarize the expression and signaling pathway and functional characteristics of the IL-22 and IL-22 receptor axis in physiological and pathological scenarios and discuss the potential to target IL-22 signaling to treat human diseases.
Springer