[HTML][HTML] Protection against colitis by CD100-dependent modulation of intraepithelial γδ T lymphocyte function
Intraepithelial γδ T lymphocytes (γδ IEL) have important roles in repair of tissue damage at
epithelial sites, such as skin and intestine. Molecules that orchestrate these γδ T-cell
functions are not well defined. Recently, interaction of the semaphorin CD100 on skin γδ T
cells with plexin B2 on keratinocytes was shown to be important for effective γδ T-cell
function in the epidermis, which raised the possibility that CD100 may exert similar functions
in the intestinal tract. In this study, we find that CD100 is expressed on all IEL, and plexin B2 …
epithelial sites, such as skin and intestine. Molecules that orchestrate these γδ T-cell
functions are not well defined. Recently, interaction of the semaphorin CD100 on skin γδ T
cells with plexin B2 on keratinocytes was shown to be important for effective γδ T-cell
function in the epidermis, which raised the possibility that CD100 may exert similar functions
in the intestinal tract. In this study, we find that CD100 is expressed on all IEL, and plexin B2 …