Modulation of epithelial cell growth by intraepithelial γδ T cells
R Boismenu, WL Havran - Science, 1994 - science.org
R Boismenu, WL Havran
Science, 1994•science.orgThe role played in immune surveillance by γδ T cells residing in various epithelia has not
been clear. It is shown here that activated γδ T cells obtained from skin and intestine express
the epithelial cell mitogen keratinocyte growth factor (KGF). In contrast, intraepithelial αβ T
cells, as well as all lymphoid αβ and γδ T cell populations tested, did not produce KGF or
promote the growth of cultured epithelial cells. These results suggest that intraepithelial γδ T
cells function in surveillance and in repair of damaged epithelial tissues.
been clear. It is shown here that activated γδ T cells obtained from skin and intestine express
the epithelial cell mitogen keratinocyte growth factor (KGF). In contrast, intraepithelial αβ T
cells, as well as all lymphoid αβ and γδ T cell populations tested, did not produce KGF or
promote the growth of cultured epithelial cells. These results suggest that intraepithelial γδ T
cells function in surveillance and in repair of damaged epithelial tissues.
The role played in immune surveillance by γδ T cells residing in various epithelia has not been clear. It is shown here that activated γδ T cells obtained from skin and intestine express the epithelial cell mitogen keratinocyte growth factor (KGF). In contrast, intraepithelial αβ T cells, as well as all lymphoid αβ and γδ T cell populations tested, did not produce KGF or promote the growth of cultured epithelial cells. These results suggest that intraepithelial γδ T cells function in surveillance and in repair of damaged epithelial tissues.
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