Double-negative αβ T cells are early responders to AKI and are found in human kidney
MN Martina, S Noel, A Saxena… - Journal of the …, 2016 - journals.lww.com
Ischemia-reperfusion injury (IRI) is a major cause of AKI, and previous studies established
important roles for conventional CD4+ T cells, natural killer T cells, and CD4+ CD25+
FoxP3+ Tregs in AKI pathogenesis. We recently identified CD4− CD8−(double-negative;
DN) T cells as an important subset of αβ T cell receptor–positive cells residing in mouse
kidney. However, little is known about the pathophysiologic functions of kidney DN T cells. In
this study, we phenotypically and functionally characterized murine kidney DN T cells in the …
important roles for conventional CD4+ T cells, natural killer T cells, and CD4+ CD25+
FoxP3+ Tregs in AKI pathogenesis. We recently identified CD4− CD8−(double-negative;
DN) T cells as an important subset of αβ T cell receptor–positive cells residing in mouse
kidney. However, little is known about the pathophysiologic functions of kidney DN T cells. In
this study, we phenotypically and functionally characterized murine kidney DN T cells in the …