CCR2 expression by brain microvascular endothelial cells is critical for macrophage transendothelial migration in response to CCL2

KA Dzenko, L Song, S Ge, WA Kuziel, JS Pachter - Microvascular research, 2005 - Elsevier
While the expression of chemokine receptors by endothelial cells is now well established,
little is known of the function of these receptors at this cellular locale. However, given that
chemokines are instrumental in directing leukocytes to specific parenchymal sites, one
possibility is that endothelial chemokine receptors play a role in the process of leukocyte
extravasation. To test this hypothesis, we investigated the contribution of CCR2, the major
cognate receptor for the chemokine CCL2 (formerly known as MCP-1), to CCL2-stimulated …