Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure
BACKGROUND: Despite widely reported clinical and preclinical studies of rapid
antidepressant actions of glutamate N-methyl-D-aspartate (NMDA) receptor antagonists,
there has been very little work examining the effects of these drugs in stress models of
depression that require chronic administration of antidepressants or the molecular
mechanisms that could account for the rapid responses. METHODS: We used a rat 21-day
chronic unpredictable stress (CUS) model to test the rapid actions of NMDA receptor …
antidepressant actions of glutamate N-methyl-D-aspartate (NMDA) receptor antagonists,
there has been very little work examining the effects of these drugs in stress models of
depression that require chronic administration of antidepressants or the molecular
mechanisms that could account for the rapid responses. METHODS: We used a rat 21-day
chronic unpredictable stress (CUS) model to test the rapid actions of NMDA receptor …