High heterogeneity and low reliability in the diagnosis of major depression will impair the development of new drugs

SM Lieblich, DJ Castle, C Pantelis, M Hopwood… - BJPsych …, 2015 - cambridge.org
BJPsych open, 2015cambridge.org
Major depressive disorder is a common diagnosis associated with a high burden of disease
that has proven to be highly heterogeneous and unreliable. Treatments currently available
demonstrate limited efficacy and effectiveness. New drug development is urgently required
but is likely to be hindered by diagnostic limitations.
Major depressive disorder is a common diagnosis associated with a high burden of disease that has proven to be highly heterogeneous and unreliable. Treatments currently available demonstrate limited efficacy and effectiveness. New drug development is urgently required but is likely to be hindered by diagnostic limitations.
Cambridge University Press