Behavioural and biochemical studies of citalopram and WAY 100635 in rat chronic mild stress model
M Papp, I Nalepa, L Antkiewicz-Michaluk… - Pharmacology …, 2002 - Elsevier
Reversal of chronic mild stress (CMS)-induced decrease of sucrose consumption has been
studied in rats after 2, 7, 14, and 35 days treatment with imipramine, citalopram (both 10
mg/kg per day, ip), WAY 100635 (0.2 mg/kg sc, bid), and citalopram plus WAY 100635.
Bmax, Kd, and functional status [cyclic AMP (cAMP) generation] of β1-adrenoceptors were
assessed in cortical tissue at the same time points. Citalopram reversed CMS-induced
reduction of sucrose intake at an earlier time point than imipramine. WAY 100635 was not …
studied in rats after 2, 7, 14, and 35 days treatment with imipramine, citalopram (both 10
mg/kg per day, ip), WAY 100635 (0.2 mg/kg sc, bid), and citalopram plus WAY 100635.
Bmax, Kd, and functional status [cyclic AMP (cAMP) generation] of β1-adrenoceptors were
assessed in cortical tissue at the same time points. Citalopram reversed CMS-induced
reduction of sucrose intake at an earlier time point than imipramine. WAY 100635 was not …