Testing for linkage and association with rheumatoid arthritis a ptpn22 promoter polymorphism reported to be associated and linked with type 1 diabetes in the …
P Dieude, VH Teixeira, C Pierlot, F Cornélis… - Annals of the …, 2008 - ard.bmj.com
Annals of the rheumatic diseases, 2008•ard.bmj.com
of transmission was observed for the–1123G allele in this subgroup. The GRR analysis
showed no increased frequency of genotypes carrying one or two–1123G alleles (data not
shown). No RA linkage was observed as none of the haplotypes was overtransmitted.
However, PTPN22 linkage to RF+ RA was significant for the haplotype carrying both–1123G
and+ 1858T alleles (p= 0.03).
showed no increased frequency of genotypes carrying one or two–1123G alleles (data not
shown). No RA linkage was observed as none of the haplotypes was overtransmitted.
However, PTPN22 linkage to RF+ RA was significant for the haplotype carrying both–1123G
and+ 1858T alleles (p= 0.03).
of transmission was observed for the–1123G allele in this subgroup. The GRR analysis showed no increased frequency of genotypes carrying one or two–1123G alleles (data not shown). No RA linkage was observed as none of the haplotypes was overtransmitted. However, PTPN22 linkage to RF+ RA was significant for the haplotype carrying both–1123G and+ 1858T alleles (p= 0.03).
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