Background Endogenous oxalate synthesis contributes to calcium oxalate stone disease
and is markedly increased in the inherited primary hyperoxaluria (PH) disorders. The
incomplete knowledge regarding oxalate synthesis complicates discovery of new
treatments. Hydroxyproline (Hyp) metabolism results in the formation of oxalate and
glycolate. However, the relative contribution of Hyp metabolism to endogenous oxalate and
glycolate synthesis is not known. Methods To define this contribution, we performed primed …