Ethylene glycol intoxication: evaluation of kinetics and crystalluria
D Jacobsen, TP Hewlett, R Webb, ST Brown… - The American journal of …, 1988 - Elsevier
Ethylene glycol and glycolate kinetics were studied in two cases of ethylene glycol
intoxication with maximal ethylene glycol/glycolate concentrations of 40.9 26.8 and 56.4
22.4 mmol/liter, respectively. Both patients survived, but with prolonged renal failure, upon
treatment with bicarbonate, ethanol, and hemodialysis. Glycolic acid was the major cause of
the metabolic acidosis in both cases; lactate levels were only slightly elevated. Kinetic
calculations showed that both ethylene glycol and glycolate were distributed in total body …
intoxication with maximal ethylene glycol/glycolate concentrations of 40.9 26.8 and 56.4
22.4 mmol/liter, respectively. Both patients survived, but with prolonged renal failure, upon
treatment with bicarbonate, ethanol, and hemodialysis. Glycolic acid was the major cause of
the metabolic acidosis in both cases; lactate levels were only slightly elevated. Kinetic
calculations showed that both ethylene glycol and glycolate were distributed in total body …