[HTML][HTML] Pan-cancer transcriptome analysis reveals a gene expression signature for the identification of tumor tissue origin
Carcinoma of unknown primary, wherein metastatic disease is present without an
identifiable primary site, accounts for~ 3–5% of all cancer diagnoses. Despite the
development of multiple diagnostic workups, the success rate of primary site identification
remains low. Determining the origin of tumor tissue is, thus, an important clinical application
of molecular diagnostics. Previous studies have paved the way for gene expression-based
tumor type classification. In this study, we have established a comprehensive database …
identifiable primary site, accounts for~ 3–5% of all cancer diagnoses. Despite the
development of multiple diagnostic workups, the success rate of primary site identification
remains low. Determining the origin of tumor tissue is, thus, an important clinical application
of molecular diagnostics. Previous studies have paved the way for gene expression-based
tumor type classification. In this study, we have established a comprehensive database …