[HTML][HTML] Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung …
DMJ Curfs, SAI Ghesquiere, MN Vergouwe… - Journal of biological …, 2008 - ASBMB
Secreted phospholipase A2 group X (sPLA 2-X) is one of the most potent enzymes of the
phospholipase A 2 lipolytic enzyme superfamily. Its high catalytic activity toward
phosphatidylcholine (PC), the major phospholipid of cell membranes and low-density
lipoproteins (LDL), has implicated sPLA 2-X in chronic inflammatory conditions such as
atherogenesis. We studied the role of sPLA 2-X enzyme activity in vitro and in vivo, by
generating sPLA 2-X-overexpressing macrophages and transgenic macrophage-specific …
phospholipase A 2 lipolytic enzyme superfamily. Its high catalytic activity toward
phosphatidylcholine (PC), the major phospholipid of cell membranes and low-density
lipoproteins (LDL), has implicated sPLA 2-X in chronic inflammatory conditions such as
atherogenesis. We studied the role of sPLA 2-X enzyme activity in vitro and in vivo, by
generating sPLA 2-X-overexpressing macrophages and transgenic macrophage-specific …