Diazepam binding inhibitor overexpression in mice causes hydrocephalus, decreases plasticity in excitatory synapses and impairs hippocampus-dependent learning
H Siiskonen, S Oikari, VP Korhonen, A Pitkänen… - Molecular and Cellular …, 2007 - Elsevier
Diazepam binding inhibitor (DBI) and its processing products are endogenous modulators of
GABAA and linked to various brain disorders ranging from anxiety and drug dependence to
epilepsy. To investigate the physiological role of endogenously expressed DBI in the brain
we created a transgenic mouse line overexpressing DBI gene. Transgenic mice had a 37×
increased protein expression and immunohistochemistry showed excessive glial expression
in the infragranular region of the dentate gyrus. Transgenic animals had significantly larger …
GABAA and linked to various brain disorders ranging from anxiety and drug dependence to
epilepsy. To investigate the physiological role of endogenously expressed DBI in the brain
we created a transgenic mouse line overexpressing DBI gene. Transgenic mice had a 37×
increased protein expression and immunohistochemistry showed excessive glial expression
in the infragranular region of the dentate gyrus. Transgenic animals had significantly larger …