Notch in the kidney: development and disease

Y Sirin, K Susztak - The Journal of pathology, 2012 - Wiley Online Library
Y Sirin, K Susztak
The Journal of pathology, 2012Wiley Online Library
Notch signalling is a highly conserved cell–cell communication mechanism that regulates
development, tissue homeostasis, and repair. Within the kidney, Notch has an important
function in orchestrating kidney development. Recent studies indicate that Notch plays a key
role in establishing proximal epithelial fate during nephron segmentation as well as the
differentiation of principal cells in the renal collecting system. Notch signalling is markedly
reduced in the adult kidney; however, increased Notch signalling has been noted in both …
Abstract
Notch signalling is a highly conserved cell–cell communication mechanism that regulates development, tissue homeostasis, and repair. Within the kidney, Notch has an important function in orchestrating kidney development. Recent studies indicate that Notch plays a key role in establishing proximal epithelial fate during nephron segmentation as well as the differentiation of principal cells in the renal collecting system. Notch signalling is markedly reduced in the adult kidney; however, increased Notch signalling has been noted in both acute and chronic kidney injury. Increased glomerular epithelial Notch signalling has been associated with albuminuria and glomerulosclerosis, while tubular epithelial Notch activation caused fibrosis development most likely inducing an improper epithelial repair pathway. Recent studies thereby indicate that Notch is a key regulator of kidney development, repair, and injury. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Wiley Online Library