[PDF][PDF] Ozz: A new name on the long list of β-catenin's nemeses
G Wu, C Liu, X He - Molecular cell, 2004 - cell.com
G Wu, C Liu, X He
Molecular cell, 2004•cell.comIn the February issue of Developmental Cell, Nastasi et al. describe Ozz, a muscle-specific
ubiquitin ligase adaptor that regulates myofibril organization. Ozz appears to function in
ubiquitination and degradation of membrane-bound, but not cytosolic, β-catenin, whose
turnover may be required for alignment and growth of the sarcomere, the basic contractile
unit of myofibers.
ubiquitin ligase adaptor that regulates myofibril organization. Ozz appears to function in
ubiquitination and degradation of membrane-bound, but not cytosolic, β-catenin, whose
turnover may be required for alignment and growth of the sarcomere, the basic contractile
unit of myofibers.
Abstract
In the February issue of Developmental Cell, Nastasi et al. describe Ozz, a muscle-specific ubiquitin ligase adaptor that regulates myofibril organization. Ozz appears to function in ubiquitination and degradation of membrane-bound, but not cytosolic, β-catenin, whose turnover may be required for alignment and growth of the sarcomere, the basic contractile unit of myofibers.
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