Cardiovascular effects of tadalafil

RA Kloner, M Mitchell, JT Emmick - The American journal of cardiology, 2003 - Elsevier
To determine the effects of tadalafil on the cardiovascular system, safety assessments were
performed on a database of> 4,000 subjects who received tadalafil in> 60 clinical
pharmacology, phase 2, phase 3, and open-label studies. In healthy subjects, tadalafil
resulted in small changes in blood pressure, which are not believed to be clinically relevant.
Daily administration of tadalafil 20 mg for 26 weeks in healthy male subjects or patients with
mild erectile dysfunction resulted in blood pressure changes similar to those observed after …

Cardiovascular effects of tadalafil in patients on common antihypertensive therapies

RA Kloner, M Mitchell, JT Emmick - The American journal of cardiology, 2003 - Elsevier
Tadalafil is a potent, selective, reversible phosphodiesterase 5 inhibitor under investigation
for the treatment of erectile dysfunction (ED). Because some oral agents for ED have
vasodilator properties, interaction studies were performed between tadalafil and commonly
prescribed antihypertensive agents. In addition, cardiovascular safety assessments were
made from a safety database of phase 3 studies comparing patients who were and who
were not receiving antihypertensives. In patients receiving concomitant antihypertensive …

Overview of the cardiovascular effects of tadalafil

JT Emmick, SR Stuewe, M Mitchell - European Heart Journal …, 2002 - academic.oup.com
Because erectile dysfunction (ED) and cardiovascular disease share a number of risk
factors, it is important to understand the haemodynamic and cardiovascular effects of
treatments for ED, including the phosphodiesterase (PDE) type 5 inhibitors. In healthy
subjects, administration of tadalafil (a potent and selective inhibitor of PDE5 indicated for the
treatment of ED) resulted in small decreases in standing blood pressure. In the general
population of men with ED, the effects of tadalafil on haemodynamic parameters were …