A compendium of proteins that interact with HIF-1α
GL Semenza - Experimental cell research, 2017 - Elsevier
GL Semenza
Experimental cell research, 2017•ElsevierAbstract Hypoxia-inducible factor 1 (HIF-1) is the founding member of a family of
transcription factors that function as master regulators of oxygen homeostasis. HIF-1 is
composed of an O 2-regulated HIF-1α subunit and a constitutively expressed HIF-1β
subunit. This review provides a compendium of proteins that interact with the HIF-1α subunit,
many of which regulate HIF-1 activity in either an O 2-dependent or O 2-independent
manner.
transcription factors that function as master regulators of oxygen homeostasis. HIF-1 is
composed of an O 2-regulated HIF-1α subunit and a constitutively expressed HIF-1β
subunit. This review provides a compendium of proteins that interact with the HIF-1α subunit,
many of which regulate HIF-1 activity in either an O 2-dependent or O 2-independent
manner.
Abstract
Hypoxia-inducible factor 1 (HIF-1) is the founding member of a family of transcription factors that function as master regulators of oxygen homeostasis. HIF-1 is composed of an O2-regulated HIF-1α subunit and a constitutively expressed HIF-1β subunit. This review provides a compendium of proteins that interact with the HIF-1α subunit, many of which regulate HIF-1 activity in either an O2-dependent or O2-independent manner.
Elsevier