[HTML][HTML] The orphan receptor COUP-TF binds to a third glucocorticoid accessory factor element within the phosphoenolpyruvate carboxykinase gene promoter
DK Scott, JA Mitchell, DK Granner - Journal of Biological Chemistry, 1996 - ASBMB
The phosphoenolpyruvate carboxykinase (PEPCK) gene promoter contains a glucocorticoid
response unit (GRU) that includes, as a linear array, two accessory factor binding sites (AF1
and AF2) and two glucocorticoid receptor binding sites. All of these elements are required
for a complete glucocorticoid response. AF1 and AF2 also partially account for the response
of the PEPCK gene to retinoic acid and insulin, respectively. A second retinoic acid
response element was recently located just downstream of the GRU. In this study we show …
response unit (GRU) that includes, as a linear array, two accessory factor binding sites (AF1
and AF2) and two glucocorticoid receptor binding sites. All of these elements are required
for a complete glucocorticoid response. AF1 and AF2 also partially account for the response
of the PEPCK gene to retinoic acid and insulin, respectively. A second retinoic acid
response element was recently located just downstream of the GRU. In this study we show …