CSF-1R inhibition attenuates renal and neuropsychiatric disease in murine lupus
SA Chalmers, J Wen, J Shum, J Doerner, L Herlitz… - Clinical …, 2017 - Elsevier
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease that can affect
multiple end organs. Kidney and brain are two of the organs most commonly involved in
SLE. Past studies have suggested the importance of macrophages in the pathogenesis of
lupus nephritis (LN). Furthermore, as the immune effectors of the brain, microglia have been
implicated in pathways leading to neuropsychiatric SLE (NPSLE). We depleted
macrophages and microglia using GW2580, a small colony stimulating factor-1 receptor …
multiple end organs. Kidney and brain are two of the organs most commonly involved in
SLE. Past studies have suggested the importance of macrophages in the pathogenesis of
lupus nephritis (LN). Furthermore, as the immune effectors of the brain, microglia have been
implicated in pathways leading to neuropsychiatric SLE (NPSLE). We depleted
macrophages and microglia using GW2580, a small colony stimulating factor-1 receptor …