IgG4 anti-neurofascin155 antibodies in chronic inflammatory demyelinating polyradiculoneuropathy: clinical significance and diagnostic utility of a conventional assay

M Kadoya, K Kaida, H Koike, H Takazaki… - Journal of …, 2016 - Elsevier
We aimed to validate the diagnostic utility of enzyme-linked immunosorbent assay (ELISA)
for the detection of anti-neurofascin (NF) 155 antibody in 191 patients with chronic
inflammatory demyelinating polyneuropathy (CIDP). Human NF155-based ELISA clearly
distinguished between anti-NF155 antibody-positive and-negative sera. Fifteen CIDP
patients (8%) were IgG4 anti-human NF155 antibody-positive, which were confirmed by
western blot, cell-based assay and immunohistochemical study. None of disease controls or …