Paranodal lesions in chronic inflammatory demyelinating polyneuropathy associated with anti-Neurofascin 155 antibodies
JM Vallat, N Yuki, K Sekiguchi, N Kokubun, N Oka… - Neuromuscular …, 2017 - Elsevier
Abstract Antibodies to Contactin-1 and Neurofascin 155 (Nfasc155) have recently been
associated with subsets of patients with chronic inflammatory demyelinating polyneuropathy
(CIDP). Contactin-1 and Nfasc155 are cell adhesion molecules that constitute the septate-
like junctions observed by electron microscopy in the paranodes of myelinated axons.
Antibodies to Contactin-1 have been shown to affect the localization of paranodal proteins
both in patient nerve biopsies and in animal models after passive transfer. However, it is …
associated with subsets of patients with chronic inflammatory demyelinating polyneuropathy
(CIDP). Contactin-1 and Nfasc155 are cell adhesion molecules that constitute the septate-
like junctions observed by electron microscopy in the paranodes of myelinated axons.
Antibodies to Contactin-1 have been shown to affect the localization of paranodal proteins
both in patient nerve biopsies and in animal models after passive transfer. However, it is …