Quantification of B-cell maturation antigen, a target for novel chimeric antigen receptor T-cell therapy in myeloma
DA Salem, I Maric, CM Yuan, DJ Liewehr, DJ Venzon… - Leukemia research, 2018 - Elsevier
B-cell maturation antigen (BCMA) is expressed by normal and malignant plasma cells and is
targeted via anti-BCMA chimeric antigen receptor T-cell therapy (BCMA CAR T-cell therapy)
in plasma cell myeloma (PCM) patients. Surface BCMA expression is required for CAR T-
cell binding and killing. We determined the incidence and intensity of expression of BCMA in
bone marrow PCM cells using flow cytometry (FC) and immunohistochemistry (IHC). PCM
BCMA expression was assessed by FC in 70 patients and in 43 concurrent specimens by …
targeted via anti-BCMA chimeric antigen receptor T-cell therapy (BCMA CAR T-cell therapy)
in plasma cell myeloma (PCM) patients. Surface BCMA expression is required for CAR T-
cell binding and killing. We determined the incidence and intensity of expression of BCMA in
bone marrow PCM cells using flow cytometry (FC) and immunohistochemistry (IHC). PCM
BCMA expression was assessed by FC in 70 patients and in 43 concurrent specimens by …