[HTML][HTML] Transcription of the Lung-specific Surfactant Protein C Gene Is Mediated by Thyroid Transcription Factor 1 (∗)
SE Kelly, CJ Bachurski, MS Burhans… - Journal of Biological …, 1996 - ASBMB
Surfactant protein C (SP-C) is expressed in alveolar Type II epithelial cells of the lung. In
order to determine the mechanism (s) that regulate gene transcription, we have analyzed the
activation of the murine SP-C promoter in mouse lung epithelial cells (MLE cells) and in
HeLa cells after co-transfection with a vector expressing rat thyroid transcription factor-1
(TTF-1). TTF-1 transactivated SP-C-chloramphenicol acetyltransferase constructs
containing− 13 kilobase pairs to− 320 base pairs (bp) of the 5′ flanking region of the SP-C …
order to determine the mechanism (s) that regulate gene transcription, we have analyzed the
activation of the murine SP-C promoter in mouse lung epithelial cells (MLE cells) and in
HeLa cells after co-transfection with a vector expressing rat thyroid transcription factor-1
(TTF-1). TTF-1 transactivated SP-C-chloramphenicol acetyltransferase constructs
containing− 13 kilobase pairs to− 320 base pairs (bp) of the 5′ flanking region of the SP-C …