[HTML][HTML] μ Opioid receptor phosphorylation, desensitization, and ligand efficacy
Y Yu, L Zhang, X Yin, H Sun, GR Uhl… - Journal of Biological …, 1997 - ASBMB
μ opioid receptors are subject to phosphorylation and desensitization through actions of at
least two distinct biochemical pathways: agonist-dependent μ receptor phosphorylation and
desensitization induced by a biochemically distinct second pathway dependent on protein
kinase C activation (1). To better understand the nature of the agonist-induced μ receptor
phosphorylation events, we have investigated the effects of a variety of opiate ligands of
varying potencies and intrinsic activities on μ receptor phosphorylation and desensitization …
least two distinct biochemical pathways: agonist-dependent μ receptor phosphorylation and
desensitization induced by a biochemically distinct second pathway dependent on protein
kinase C activation (1). To better understand the nature of the agonist-induced μ receptor
phosphorylation events, we have investigated the effects of a variety of opiate ligands of
varying potencies and intrinsic activities on μ receptor phosphorylation and desensitization …