[HTML][HTML] Dynamic transcriptional regulatory complexes, including E2F4, p107, p130, and Sp1, control fibroblast growth factor receptor 1 gene expression during …

R Parakati, JX DiMario - Journal of Biological Chemistry, 2005 - ASBMB
Developmentally controlled transcriptional regulation of myogenic cell proliferation and
differentiation via expression of the fibroblast growth factor receptor 1 (FGFR1) gene is
positively regulated by Sp1 and negatively regulated by E2F4-based transcriptional
complexes. We report that p107 and p130 formed transcriptional complexes with E2F4 on
the FGFR1 promoter and repressed FGFR1 gene transcription in myogenic cells. However,
in Drosophila melanogaster SL2 cells, only p107 was able to repress Sp1-mediated …