Hematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human TH2 cell subpopulation with enhanced function

A Mitson-Salazar, Y Yin, DL Wansley, M Young… - Journal of Allergy and …, 2016 - Elsevier
Background IL-5+ pathogenic effector TH 2 (peT H 2) cells are a TH 2 cell subpopulation
with enhanced proinflammatory function that has largely been characterized in murine
models of allergic inflammation. Objective We sought to identify phenotype markers for
human peT H 2 cells and characterize their function in patients with allergic eosinophilic
inflammatory diseases. Methods Patients with eosinophilic gastrointestinal disease (EGID),
patients with atopic dermatitis (AD), and nonatopic healthy control (NA) subjects were …