Interleukin-26: an IL-10-related cytokine produced by Th17 cells
RP Donnelly, F Sheikh, H Dickensheets… - Cytokine & growth factor …, 2010 - Elsevier
IL-26 is classified as a member of the IL-10 cytokine family because it has limited sequence
homology to IL-10 and the IL-10-related cytokines. The human IL-26 gene, IL26, is located
on chromosome 12q15 between the genes for two other important class-2 cytokines, IFNG
(IFN-γ) and IL22 (IL-22). IL-26 is often co-expressed with IL-22 by activated T cells,
especially Th17 cells. It signals through a heterodimeric receptor complex composed of the
IL-20R1 and IL-10R2 chains. IL-26 receptors are primarily expressed on non-hematopoietic …
homology to IL-10 and the IL-10-related cytokines. The human IL-26 gene, IL26, is located
on chromosome 12q15 between the genes for two other important class-2 cytokines, IFNG
(IFN-γ) and IL22 (IL-22). IL-26 is often co-expressed with IL-22 by activated T cells,
especially Th17 cells. It signals through a heterodimeric receptor complex composed of the
IL-20R1 and IL-10R2 chains. IL-26 receptors are primarily expressed on non-hematopoietic …