[HTML][HTML] Staphylococcus aureus subvert autophagy for induction of caspase-independent host cell death

A Schnaith, H Kashkar, SA Leggio, K Addicks… - Journal of Biological …, 2007 - ASBMB
Staphylococcus aureus is a common bacterial etiology of serious infectious diseases. S.
aureus can invade various types of non-professional phagocytes to produce host cell death.
We show here that shortly after invasion of HeLa cells S. aureus transit to autophagosomes
was characterized by double membranes and co-localization with LC3. S. aureus were not
able to replicate and produce cell death in autophagy-deficient atg5-/-mouse embryonic
fibroblasts. S. aureus-containing autophagosomes do not acidify nor do they acquire …